ea0016p282 | Endocrine tumours | ECE2008
Cordella Daniela
, De Marco Alessandro
, Eller-Vainicher Cristina
, Bastagli Anna
, Jaffrain-Rea Marie Lise
, Beck-Peccoz Paolo
, Persani Luca
Multiple endocrine neoplasia type 1 (MEN1) is a rare dominantly inherited neoplastic syndrome. Tipically, it affects three major locations: parathyroid, endocrine pancreas or duodenum (GEP) and anterior pituitary. MEN1 is caused by mutations in MEN1 gene and its testing is now used as a complement to clinical diagnosis which may be hindered by the variable penetrance and expression of the defects. Mutation carriers are life-long monitored, while unaffected relatives can avoid ...